Purpose of the I CAN Study

The I CAN Study is evaluating the safety and effectiveness of a study medication to potentially help manage symptoms in adults who have immunoglobulin A nephropathy (IgAN). The I CAN Study was designed with feedback from patients living with IgAN and from the IgAN community.

Who May Qualify

Eligible participants must meet the following criteria:

  • Be at least 18 years of age
  • Be diagnosed with IgAN based on kidney biopsy
  • Have been treated with stable doses of the maximum allowed or tolerated blood pressure medications for more than three months before screening
  • Not have a history of kidney transplant or plan to undergo a transplant during the treatment period
  • Must have protein in their urine

There are additional eligibility requirements that the study doctor can explain to you.

Study Participation

Participation in the I CAN Study may last up to approximately four years and consists of the following periods:

Screening

Lasts approximately six weeks and includes two visits. The study team will review your medical history and perform tests to see if you qualify for the study. If you qualify, your study doctor will make sure you are receiving renin-angiotensin system inhibitor (RASi) therapy (a type of hypertensive therapy) for at least three months before study treatment may begin. You will continue taking RASi as background therapy throughout the study.

Study Treatment

Lasts approximately two years and includes 15 visits. During this period, you are randomly assigned to receive either the study medication or a placebo, which looks just like the study medication but contains no active ingredients. You should continue your stable current treatment that is consistent for your IgAN care. The study team will perform procedures and assessments during study visits to check on your health.

Ravulizumab Access

This period is optional, lasts approximately two years, and includes 14 visits. You will have the option to receive the study medication for approximately two years after the study treatment period.

Throughout the study, your study doctor may perform a number of tests and procedures, including but not limited to:

  • Recording your medical history

  • Conducting physical exams

  • Measuring your vital signs

  • Conducting pregnancy tests (if applicable)

  • Collecting blood and urine samples

See if you may qualify