About Immunoglobulin A Nephropathy

Immunoglobulin A nephropathy (IgAN), also known as Berger’s disease, is an immune-mediated disease – a disease caused by abnormal activity of the immune system. IgAN occurs when immunoglobulin A (IgA), an antibody normally produced by the immune system to fight against bacteria and viruses, builds up in the kidneys and causes inflammation and damage. IgAN can lead to kidney failure, at which point a patient will need either a kidney transplant or a blood-filtering treatment called dialysis.^Footnote1

Common symptoms for IgAN include high blood pressure, fatigue, blood in urine (hematuria), and high level of protein in urine (proteinuria). IgAN can occur at any age. Symptoms of IgAN may not appear for years or even decades.^Footnote1

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